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Background informationSox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
SynonymsICA 12; ICA12; Islet cell antibody 12; Islet cell antigen 12; MGC117216; SOX 13; SOX 13 protein; sox13; SOX13 protein; SOX13_HUMAN; SRY Sex determining region Y-box 13; SRY box 13; SRY box containing gene 13; SRY related HMG box gene 13; SRY sex determining region Y box 13; Transcription factor SOX 13; Transcription factor Sox-13; Type 1 diabetes autoantigen; Type 1 diabetes autoantigen ICA 12; Type 1 diabetes autoantigen ICA12.
AdvisoryAvoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
Cross Reactive Species detailsNo significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
AboutPolyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
StorageWater buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Cross reactive speciesHuman (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
Antigen SourceKLH conjugated synthetic peptide derived from human ICA12
SpecificityThis antibody reacts specifically with ICA12/SOX13
ModificationNo modification has been applied to this antibody
PropertiesFor facs or microscopy Alexa 1 conjugate.
Also known asICA12/SOX13 Polyclonal Antibody
Host organismRabbit (Oryctolagus cuniculus)
ConjugationAlexa Fluor,ALEXA FLUOR® 594
Other nameAnti-ICA12/SOX13 Polyclonal
TypeConjugated Primary Antibody
GroupPolyclonals and antibodies
Purification methodPurified by Protein A.
ClonePolyclonal Antibodies
ClonalityPolyclonal Antibody
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Conjugated withALEXA FLUOR® 594
ConjugatedAlexa conjugate 1
Concentration1ug per 1ul
Excitation emission590nm/617nm
Target Protein/PeptideICA12/SOX13
Modification siteNone
Swiss ProtN/A
Gene IDN/A
Subcellular locationsN/A