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NameDescription
DescriptionTranscription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
StorageAliquot the anti-SOX-2 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
Species reactivityHuman (Homo sapiens), Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
Additional descriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
ImmunogenThis anti-SOX-2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 6~39 amino acids from the N-terminal region of mouse Sox2.
PropertiesIf you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
NotesTitration of the anti-SOX-2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Intented useThis anti-SOX-2 antibodyis to be used only for research purposes and not for diagnostics..
ConcentrationIn 1X PBS, pH 7.4, with 0.09% sodium azide
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
FormAntigen affinity purified
Recommended dilutionsWestern blot: 1:1000
ClonePolyclonal antibody
PurityAntigen affinity
ConjugationUnconjugated
Recognised antigenAnti-SOX-2
French translationanticorps
Tested applicationsWB, ELISA
CategoryAntibody
Uniprot #P48432