| Description |
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). |
| Storage |
Aliquot the anti-SOX-2 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. |
| Species reactivity |
Human (Homo sapiens), Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur. |
| Additional description |
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. |
| Immunogen |
This anti-SOX-2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 6~39 amino acids from the N-terminal region of mouse Sox2. |
| Properties |
If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. |
| Notes |
Titration of the anti-SOX-2 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Intented use |
This anti-SOX-2 antibodyis to be used only for research purposes and not for diagnostics.. |
| Concentration |
In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Host animal |
Rabbit (Oryctolagus cuniculus) |
| Clonality |
Polyclonal (rabbit origin) |
| Form |
Antigen affinity purified |
| Recommended dilutions |
Western blot: 1:1000 |
| Clone |
Polyclonal antibody |
| Purity |
Antigen affinity |
| Conjugation |
Unconjugated |
| Recognised antigen |
Anti-SOX-2 |
| French translation |
anticorps |
| Tested applications |
WB, ELISA |
| Category |
Antibody |
| Uniprot # |
P48432 |
